Dr. Harvey Knull
Dean of Graduate Studies and Associate VP for Research & Scholarly Activity

Graduate Studies & Research
Texas A&M University-Corpus Christi
6300 Ocean Drive, Natural Resource Center Suite 2700
(361)825-2177
Harvey.Knull@tamucc.edu

EDUCATION | PROFESSIONAL EXPERIENCE | AWARDS | PROFESSIONAL ACTIVITIES | GRANTS | SYMPOSIUM PRESENTATIONS | THESES | PUBLICATIONS | PUBLISHED ABSTRACTS | RESEARCH SEMINARS | SUPERVISORY ACTIVITIES FOR GRADUATE STUDENTS | UNDERGRADUATE STUDENT RESEARCH SUPERVISION | SUPERVISORY ACTIVITIES | GRADUATE STUDENT COMMITTEES | COMMITTEES AT UND | PROFESSIONAL ORGANIZATIONS | OTHER ORGANIZATIONS | Seminar/Lecture/Roundtable

 
EDUCATION
Pennsylvania State University Ph.D. Biochemistry, 1970. Advisor: Dr. John Pazur
University of Nebraska Agronomy doctoral student, 1965-66. Advisor: Dr. Ed Kinbacher
University of Nebraska M.S., Horticulture, 1965 Advisor: Dr. Ed Kinbacher
University of Alberta B.S., Agriculture, 1963 Advisor: Dr. William Andrews
 
PROFESSIONAL EXPERIENCE
1970 Pennsylvania State Univ., Postdoc with Dr. J.H. Pazur - Biochemistry
1970-73 Michigan State Univ., Postdoc with Dr. W.W. Wells - Biochemistry
1973-78 Univ. of Manitoba, Dental School Ass't./Assoc. Professor, Dept. of Oral Biology.
1980-2000 Univ. of North Dakota,
School of Medicine		 Various Positions, See Below
1980-87 Univ. of North Dakota Assoc./Full Professor, Biochem and Molecular Biology
1988-91 Univ. of North Dakota Biochemistry Graduate Program Coordinator
1990-00 Univ. of North Dakota Dean of Graduate School
1996 Univ. of North Dakota Research Office assigned to report to me
2000-present Texas A&M Univ - Corpus Christi Graduate Dean and Assoc VP Research
 
AWARDS
  • University of North Dakota Chester Fritz Distinguished Professor, 1988.
  • University of North Dakota Outstanding Scientific Research Award for 1987. Presented by the UND Chapter of Sigma Xi.
PROFESSIONAL ACTIVITIES
  • President-University of North Dakota Chapter of Sigma Xi (1985-86).
    Gordon Conference Participant in- "Enzyme Organization and Cell Function"
              - 1991 Meeting Vice Chair,
              - 1993 Meeting Chair - Selected speakers, set the program and solicited funding.
    North Dakota EPSCoR steering committee - (1991-00) Chair 1992-00
  • Ad hoc reviewer for Biochimica Biophysica Acta, Journal of Cellular Biochemistry, Journal of Neurochemistry, Canadian Journal of Biochemistry and Cell Biology, Journal of Dental Research, Journal of Biological Chemistry, Archives of Biochemistry and Biophysics, FASEB Journal, American Journal of Physiology, Molecular and Cellular Biochemistry, Analytical Biochemistry, and Comparative Biochemistry and Physiology. Biochemistry
  • Ad hoc grant reviewer for National Science Foundation (every year since 1989), Veterans Administration, Medical Research Council of Canada, Manitoba Research Council.
  • Site Visitor for the NIH, June 1989. - NIH Study Section member 1989.
  • Invited Delegate to the Annual Sigma Xi Convention. Memphis, TN. 1986. Round Table Contributor to A new Agenda for Science: Who plays, who pays, who sets the rules? Centennial Meeting of Sigma Xi. 1987. Washington DC.
  • Session Chair on Subcellular Organization at Third International Conference on Molecular Recognition: Biological importance of dynamics of molecular and submolecular processes. 1997 Pecs, Hungary.
  • Session Chair at Gordon Conference on "Enzyme Organization and Cell Function" 1998 Oxford, England.
 
GRANTS
  • Department of Education 2000-2003. GAANN program for Chemistry at UND. $545,598. PI Harmon Abrahamson, Co-PI, H. Knull.
  • NIH 1997-2000. Brownian dynamics simulations of actin with aldolase. $105,975 Collaborating Investigator with Kathryn Thomasson as the PI.
  • NSF (EPSCoR) 1995-98. Supramolecular Protein Complexes: Roles in Cellular Regulation. Co-PIs, H.Knull, J.Shabb, R.C.Nordlie, D.O.Lambeth, P.D.Ray, B.I.Milavetz, S.Detke, D.K.Srivastava, K.Thomasson, K.Sukalski, and D.Killilea. Administered by Knull and Shabb. $1,474,000.
  • NSF (EPSCoR) 1992-95. Supramolecular Protein Complexes: Roles in Cellular Regulation. Co-PIs, H.Knull, J.Shabb, R.C.Nordlie, D.O.Lambeth, P.D.Ray, B.I.Milavetz, S.Detke, D.K.Srivastava, and D.Killilea. Administered by Knull. $1,446,830.
  • NSF 1995-98. Enhancement of Science and Mathematics for Fourth and Fifth Grade Native American Students with Disabilities. PI, Sue Schmitt, Co-PI with 5 others. $1,336,552
  • WICHE Doctoral Teaching Fellowships. 1994-1997, $84,000 ($28,000 annually)
  • Patricia Roberts Harris Fellowship. 1990-1998. (US Department of Education). Graduate Fellowships to support minorities and women in under represented areas. $855,576
  • EPSCoR (NSF) 1991. Summer Visiting Professor (Dr. Steve Lowe from Minot State University), $4,800
  • EPSCoR 1990-91. "Compartments for Glycolytic Enzymes in the CNS". $27,400
  • Thelin Research Fund. 1989-90. Interaction between Glycolytic Enzymes and the Cytoskeleton. $16,750.
  • North Dakota Lions Foundation. 1988-91. Glycosylation of cytoarchitectural proteins in the nervous system. $27,900.
  • American Diabetes Association, North Dakota Affiliate. 1990-91. Glycosylation of cytoarchitectural proteins in the nervous system. $10,000.
  • American Diabetes Association, Inc. 1986-1988. "Glycosylation of Cytoarchitectural Proteins in the Nervous System in Diabetes". $50,000.
  • NIH 1986-89."Glycolytic Enzyme Binding to Actin and Clathrin in the brain". $118,935.
  • National Institutes of Health Small Instrument Program. P.I.: Knull, H.; Co-investigator: R.C. Nordlie. 1987 - $5,054. 1988 - $5,000. 1989 - $6,003.
  • American Diabetes Association - North Dakota Affiliate. 1986, 1989, 1990. Summer student award for Study of Nonenzymatic Glycosylation - $1800/yr.
  • The Neuropsychiatric Inst. Summer Student Award: 1986 - $1500; 1987 - $900.
  • EPSCoR 1986-1989. "Compartments for Glycolytic Enzymes in the CNS". $3,000.
  • NIH. 1982-1985. "Glycolytic - NIH 1982-1985. Enzyme Binding to Actin & Clathrin". $130,031.
  • University of North Dakota, Faculty of Medicine 1980-1982. "Compartmentation of Glycolysis in the Brain." $3032.
  • Medical Research Council of Canada, 1975-1980. "Regulation of Brain Energy Metabolism". $126,800.
  • Mrs. James A. Richardson Foundation, 1976-1977. "Evaluation of Metabolites Relevant to Hemoglobin Function: Relationships to Downs Syndrome". $3,300.
  • University of Manitoba Research Board, 1973-1975. "Energy Metabolism in Relation to Cell Growth and Development in the Brain." $7600.
  • University of North Dakota. 1985. Travel Grant for graduate students to attend and present papers at Midwest Biochemists Mtg at Vermillion, SD. $900.
  • University of North Dakota and ASEND. 1987. Travel Grant for Graduate Students to present papers at PAABS/CFBS meeting in Winnipeg, Canada. $1400.
  • University of North Dakota and ASEND. 1989. Travel Grant for Graduate Students to attend and present papers at the Amer Chem Soc Mtg in Duluth MN. $1600.
 
SYMPOSIUM PRESENTATIONS
  • Knull, H.R. 1996. "Glycolytic enzyme-cytoskeleton interactions and control of metabolism." Gordon Conference on Macromolecular Organization and Cell Function, Oxford, England.
  • Knull, H.R. 1993. "Interactions of glycolytic enzymes with tubulin: Role of the tubulin C-terminals." First International Conference on "Molecular Recognition: Biological importance of dynamics of molecular and submolecular processes." Pecs, Hungary. Chair Macromolecular Organization session 1997 Meeting.
  • Knull, H.R. 1989. "Interaction of glycolytic enzymes with actin and tubulin". Int Symposium on Molecular Organization of Biological Structures. Moscow,USSR.
  • Knull, H.R. 1989. "Glycolytic Enzyme-Cytoskeleton Interactions. UCLA Conference Keystone, Colorado.
  • Knull, H.R. 1987. "Compartmentation of Glycolytic Enzymes in the Brain." Gordon Conference on Enzyme Organization and Cell Function, Santa Barbara, CA.
  • Knull, H.R. 1986. "Glycolytic Enzyme-Cytomatrix Interactions." Int. Cell and Tissue Culture Conf. Hershey, PA
  • Knull, H.R. 1983. "Muscle Energy Metabolism: Relationship to Exercise", presented in a Symposium on Effects of Exercise on Muscle at the North Dakota Academy of Sciences, Grand Forks, North Dakota.
 
THESES
  • MS - Effects of Sub-optimal Temperatures on the Amino Acid Composition of Phaseolus vulgaris seedlings - 1965
  • PhD - Biosynthesis of alpha-1,4 glucan glucohydrolase in Aspergillus niger - 1970
 
PUBLICATIONS
  • Waingeh, V. F., Gustafson, C. D., Kozliak, E. I., Lowe, S. I., Knull, H. R., Thomasson, K. A.. 2006. Biophysical Journal 90, 1371-1384.
  • Clegg, J. Kell, D., Knull, H.R., Welsh, G.R., Wilson, J. 2001 Macromolecular Interactions: Tracing the roots. TIBS 26, 91
  • Ouporov, H. Knull, S. L. Lowe, K. Thomasson. 2001 "Interactions of Glyceraldehyde-3-phosphate Dehydrogenase with G- and F-actin Predicted by Brownian Dynamics." J. Molecular Recognition, 14, 29-41
  • Ouporov, T. Kieth, H. Knull, K. Thomasson. 2000 "Computer Simulations of Glycolytic Enzyme Interactions with F-actin." J. Biomolecular Structure and Dynamics 18, 311-323.
  • Ouporov, I.V. Knull, H.R. and Thomasson, K.A. 1999. Brownian Dynamics Simulations of the Specific Interactions Between Rabbit Aldolase and G- or F-Actin. Biophysical Journal 76, 17-27.
  • Srere, P.A. and Knull, H.R. 1998 Location, Location, Location. Trends in Biochemical Sciences 23, 319-320
  • Volker, K.W. and Knull, H.R. 1997. The glycolytic enzyme binding domain of tubulin. Arch. Biochem. Biophys. 338, 237-243.
  • Knull, H.R. and Minton, A. 1996. Structure within eukaryotic cytoplasm and its relationship to glycolytic metabolism. Cell Biochemistry and Function. 14, 237-248.
  • Volker, K.W., Reinitz, C.A., and Knull H.R. 1995. Glycolytic enzymes and assembly of microtubule networks. Comp. Biochem and Biophys. 112, 503-514.
  • Marmillot, P., Keith, T., Srivastava, D.K., and Knull, H.R. 1994. Effect of tubulin on the activity of the muscle isoenzyme of lactate dehydrogenase. Arch. Biochem. Biophys. 315, 467-472.
  • Muronetz, V.I., Wang, Z., Keith, T.J., Knull, H.R., and Srivastava, D.K. 1994. Binding constants and stoichiometries of glyceraldehyde 3-phosphate dehydrogenase-tubulin complexes. Arch. Biochem. Biophys. 313, 253-260.
  • Volker, K.W. and Knull, H.R. 1993. Glycolytic enzyme-tubulin interactions: Role of the carboxyl terminals. J. Molecular Recognition. 6, 167-177.
  • Carr, D. and Knull, H.R. 1993. Aldolase-tubulin interactions: Removal of the C-terminals impairs interactions. Biochem. Biophys. Res. Comm. 195, 289-293.
  • Knull, H.R. and Walsh, J.L. 1992. Association of Glycolytic Enzymes with the Cytoskeleton. "From metabolite to metabolism to metabolon." (Issue honoring Paul Srere's 65th birthday) Curr. Top. Cell. Reg. 33, 15-28.
  • Brown, M.R. and Knull, H.R. 1992. Actin activated ATPase activity of myosin and S-1 following non-enzymatic glycation. Biochemistry and Cell Biology 70, 617-622.
  • Brown, M.R., Keith, T.J., and Knull, H.R. 1992. Incorporation of glucose and galactose into intracellular proteins in vitro. Int. J. Neurochem. 21, 177-183.
  • Laursen, S.L., Belknap, J.K., Sampson, K.E. and Knull, H.R. 1990. Hexokinase Redistribution in vivo. Biochimica Biophysica Acta 1034, 118-121.
  • Knull, H.R. 1990. "Compartmentation of Glycolytic Enzymes in the Brain and Association with the Cytoskeletal Proteins Actin and Tubulin". Proceedings of the UCLA Symposia on Structural and Organizational Aspects of Metabolic Regulation. (Eds) P. Srere, M.E. Jones, and C. Mathews. Wiley-Lis, NY, 133, 215-228.
  • Burd, L., Kemp, R., Knull, H., & Loveless, D. A Review of the Biochemical Pathways Studied and Abnormalities Reported in Rett Syndrome. Brain and Development 1990, 12, 444-448
  • Walsh, J.L., Keith, T. and Knull, H.R. 1989 Interactions of glycolytic enzymes with microtubules. Biochimica Biophysica Acta 999, 64-70.
  • Brown, M.R., Keith, T.J., and Knull, H.R. 1989. Decreased Actin Activated Myosin ATPase Activity by Non-enzymatic Glycation. Proceedings of the Fourth International Symposium on the Maillard Reaction. Birkhauser Verlag, Basel. (P.A. Finot, ed.), p487-492.
  • Walsh, J.L. and Knull, H.R. 1988. Heteromerous Interactions Among Glycolytic Enzymes and of Glycolytic Enzymes with F-Actin: Effects of Polyethylene Glycol". Biochimica Biophysica Acta, 952, 83-91.
  • Karkhoff-Schweizer, R.R. and Knull, H.R. 1987. Interactions of Glycolytic Enzymes with Tubulin. Biochem. Biophys. Res. Comm. 146, 827-831.
  • Knull, H.R., Laursen, S.E. and Cottick, A.A. 1987. Cytomatric-Glycolytic Enzyme Interactions, Modern Cell Biology 5, 157-161.
  • Laursen, S.E., Knull, H.R. and Belknap, J.K. 1986. Sample Preparation for Inositol Measurement. Analytical Biochemistry, 153, 387-390.
  • Knull, H.R. 1985. Detergent Mediated Extraction of Glycolytic Enzymes from Brain Slices and Mouse Fibroblast 3T3 Cells: Use of Myoinositol as a Marker of Membrane Porosity. Journal of Neurochemistry, 45, 1433-1440.
  • Knull, H.R. 1985. Interaction of Glycolytic Enzymes with Purified Clathrin Coated Vesicles. Neurochemistry International. 7, 379-383.
  • Knull, H.R. and Fillmore, S.J. 1985. Glycolytic Enzyme Levels in Synaptosomes. Comp. Biochem. and Physiol. 81B, 349-351.
  • Brumback, R.A., Gerst, J.W. and Knull, H.R. 1983. Creatine Phosphate and Adenosine Triphosphate Depletion by Exercise in an Animal Model of Glycolytic Insufficiency. Muscle and Nerve, 6, 52-55.
  • Knull, H.R. and Khandelwal. R. 1982. Glycogen Metabolizing Enzymes in Brain. Neurochem. Res. 7, 1307-1317.
  • Bronstein, W.W. and Knull, H.R. 1981. Interaction of Muscle Glycolytic Enzymes with Thin Filament Proteins. Can. J. Biochem. 59, 494-499.
  • Knull, H.R. 1980. Compartmentation of Glycolytic Enzymes in Nerve Endings as Determined by Glutaraldehyde Fixation. J. Biol. Chem. 255, 6439-6444.
  • Dawes, C., Dowse, C.M. and Knull, H.R. 1980. The Effects of Stop-Flow on Salivary Composition and Hydrostatic Pressures in Human Parotid and Submandibular Glands. Arch. of Oral Biol. 25, 251-256.
  • Knull, H.R. and Lamb, S.M. 1980. Hexokinases of the Major Salivary Glands. Comp. Biochem. Physiol. 65B, 743-746.
  • Knull, H.R. 1980. The Role of the Muscle Type Lactate Dehydrogenase Subunit. Trends in Biochemical Sciences, 5, IX.
  • Knull, H.R., Bronstein, W.W., DesJardins, P. and Niehaus, W.G. 1980. Interaction of Selected Brain Glycolytic Enzymes with F-actin-tropomyosin. Journal of Neurochemistry, 34, 222-225.
  • Knull, H.R. 1979. Level of Glycogen, ATP and Lactate in Control and Diabetic Rat Submandibular and Sublingual Glands. IRCS Med. Sci. 7, 565.
  • Khandelwal, R.K., Zinman,l S. and Knull, H.R. 1979. The Effect of Streptozotocin Induced Diabetes on Glycogen Metabolism in Rat Kidney and Its Relationship to the Liver System. Archives of Biochem. 197, 310-316.
  • Knull, H.R. 1978. Association of Glycolytic Enzymes with Particulate Fractions from Nerve Endings. Biochim. Biophys. Acta 522, 1-9.
  • Knull, H.R., Bronstein, W.E. and Porter, P. 1978. Adenosine Triphosphate and Diphosphoglycerate Levels in Red Blood Cells from Trisomic Mongoloids. Experientia 34, 11331-1134.
  • Knull, H.R. 1977. Pyruvate Kinase Binding to Particles in Brain. Neurochemical Research 2, 461-467.
  • Pazur, J.H., Knull, H.R. and Chevalier, G.E. 1977. The Oxidation of Aldoses, Alditols and Sugar Nucleotides by Galactose Oxidase. J. Carbohydrates Nucleosides and Nucleotides 4, 129-146.
  • Knull, H.R. and Bose, D. 1975. Biochemical and Mechanical Studies on Smooth Muscle during Hypoxia and Recovery. Am. J. Physiol. 229, 329-333.
  • Knull, H.R. and Wells, W.W. 1975. Axonal Transport of Cations in the Chick Optic System. Brain Research 100, 121-124.
  • Knull, H.R., Taylor, W.F. and Wells, W.W. 1974. Insulin Effects on Brain Energy Metabolism and the Related Changes in Hexokinase Distribution. J. Biol. Chem. 249, 6930-6935.
  • Knull, H.R., Lobert, P.F. and Wells, W.W. 1974. Galactose Neurotoxicity in Chicks: Effects on Fast Axoplasmic Transport. Brain Research 79, 524-527.
  • Kellogg, E.W., Knull, H.R. and Wilson, J.E. 1974. Soluble and Particulate Hexokinase in Developing Neural Systems. J. Neurochem. 22, 461-463.
  • Knull, H.R., Taylor, W.F. and Wells, W.W. 1973. Effect of Energy Metabolism on in vivo Distribution of Hexokinase in Brain. J. Biol. Chem. 248, 5414-5418.
  • Knull, H.R. and Wells, W.W. 1973. Recovery from Galactose-Induced Neurotoxicity in the Chick by the Administration of Glucose. J. Neurochem. 20, 415-423.
  • Knull, H., Wells, W. and Kozak, L. 1972. Galactose Neurotoxicity in the Chick: Hypersomolality or Depressed Brain Energy Reserves. Science 176, 815-816.
  • Pazur, J.H., Knull, H.R. and Cepure, A. 1971. Glycoenzymes: Structure and Properties of the Two Forms of Glucoamylase from Aspergillus niger. Carbohydrate Res. 20, 83-96.
  • Knull, H.R. and Pazur, J.H. 1971. Two-Dimensional Paper Chromatography for the Detection of Oxidation of Maltose by Glucose Oxidase. J. Chrom. 55, 425-428.
  • Pazur, J.H., Knull, H.R. and Simpson, D.L. 1970. Glycoenzymes: A Role for the Carbohydrate Moieties. Biochem.Biophys.Res.Comm. 40, 110-116.
  • Pazur, J., Simpson, D. and Knull, H. 1969. Biosynthesis of Glucohydrolase I, A Glycoenzyme from Aspergillus niger. Biochem.Biophys.Res.Comm. 36, 394-400.
  • Knull, H. and Kinbacher, E. 1968. Effects of a suboptimal temperature on the free amino acid composition of bean seedlings. Crop. Sci. 8, 39-41.
  • Kinbacher, E., Sullivan, C. and Knull, H. 1967. Thermal Stability of Malic Dehydrogenase from Heat Hardened Phaselolus Acutifolius "Tepary Buff". Crop Sci. 7, 148-151.  
  • Victor F. Waingeh, Carol D. Gustafson, Evguenii I. Kozliak, Stephen L. Lowe, Harvey R. Knull, Kathryn A. Thomasson. 2006 Biophysical Journal 90, 1371-1384.
 
PUBLISHED ABSTRACTS: POSTER or PODIUM PRESENTATIONS
  • Ouporov,V. Knull, H. R., Thomasson,K. A. 2000 "BD Simulations of Aldolase & GAPDH Binding and the Possibility of Substrate Channeling." 44th Annual Biophysical Society Meeting, New Orleans, LA
  • Ouporov,I. V., Knull, H. R.,Thomasson, K.A. 2000 "BD Simulations of aldolase and GAPDH and the possibility of substrate channeling." American Chemical Society, Great Lakes Regional Meeting, Fargo, ND
  • Ouporov,I.V., Knull, H.R. and Thomasson.K.A. 2000. Simulations of aldolase and GAPDH binding and the possibility of substrate channeling. Biophys J. 292A
  • Volker, K.W., and Knull, H. 1996. Tyrosine phosphorylation of tubulin by ZAP-70 modulates interactions with enzymes of glycolysis. ASBMB. New Orleans, LA
  • Gustafson, C.G., Keith, T.J. and Knull, H. 1996. Glycolytic interactions with skeletal muscle and yeast F-actin. ASBMB. New Orleans, LA
  • Marmillot, P., Keith, T. and Srivatava, D.K. and Knull, H. 1994. Effect of tubulin on muscle lactate dehydrogenase activity. ASBMB. Washington, DC.
  • Volker, K.W. and Knull, H. 1993. Aldolase interaction with tubulin, microtubules and tubulin peptides. ASBMB. San Diego, CA.
  • Volker, K.W. and Knull, H. 1993. Altered affinity of glycolytic enzymes for tubulin following removal of tubulin C-terminals. Gordon Conference on Enzyme Organization and Cell Function. Oxnard, CA.
  • Brown, M.R. and Knull, H.R. 1991. Effect of Reducing Sugars on Subfragment-1 of Myosin. Symposium on "Controversies in Etiology and Treatment of Diabetic Neuropathy" Satallite Symposium of the ADA.
  • Knull, H. and Walsh, J. 1989. Glycolytic enzyme interactions with F-actin and tubulin. Molecular Organization of Biological Structures. Moscow, USSR.
  • Brown, M., Keith, T. and Knull, H. 1989. Decreased Actin Activated Myosin ATPase Activity by Non-enzymatic Glycation. Fourth International Symposium on the Maillard Reaction. Lausanne, Switzerland.
  • Keith, T. and Knull, H. 1989. Glycolytic Enzyme Interactions with Microtubules. 22nd Great Lakes Regional Am. Chem. Soc. Mtg, Duluth, MN, Abst. # 164.
  • Brown, M., Keith, T. and Knull, H. 1989. Non-Enzymatic Glycation of Myosin and Actin. 22nd Great Lakes Regional Am. Chem. Soc. Mtg., Duluth, MN. Abst.# 37.
  • Carr, D. Keith, T. and Knull, H. 1989. Proteolytic Characterization of Tubulin Binding Sites for Glycolytic Enzymes. 22nd Great Lakes Regional Am. Chem. Soc. Mtg., Duluth, MN, Abst. # 24.
  • Sevigny, K. Keith, T. and Knull, H. 1989. Brain Glycolytic Enzyme Interactions with Tubulin. 22nd Great Lakes Regional Am. Chem. Soc. Mtg., Duluth, MN.
  • Laursen, S., Sampson, K., Belknap, J. and Knull, H. 1989. Effect of Ethanol on Cellular Distribution of Brain Hexokinase. 22nd Great Lake Regional Am. Chem. Soc. Mtg., Duluth, MN, Abst. # 165.
  • Knull, H.R., Walsh, J.L. and Keith, T. 1989. Glycolytic enzyme-cytoskeletal protein interactions. J. Cell. Biochem. 13E R013. UCLA Conf., Keystone, CO.
  • Knull, H.R., Karkhoff-Schweizer, R.R., and Walsh, J.L. 1988. 14th International Congress of Biochemistry, Prague, Czechoslovakia.
  • Karkhoff-Schweizer, R. and Knull, H. 1988. Association of Glyceraldehyde-3-Phosphate Dehydrogenase with Clathrin Coated Vesicles. FASEB Las Vegas, NV.
  • Walsh, J.L. and Knull, H.R. 1988. Protein Interactions Among Glycolytic Enzymes and F-Actin. FASEB Meeting, Las Vegas, NV.
  • Walsh, J.L., Korynta, D.L. and Knull, H. 1987. Polyethylene Affects Glycolytic Enzyme-Actin Associations. PAABS/Can. Fed. Biol. Sci., Winnipeg, Manitoba.
  • Knull, H.R. and Karkhoff-Schweizer, R.R. 1987. Interactions of Glycolytic Enzymes with Tubulin. PAABS/Can. Fed. Biol. Sci., Winnipeg, Manitoba.
  • Keith, T., Brown, M., Jones, M., and Knull, H. (1987). Glucitol-Lysine: Synthesis and Preparation of Derviatives. Minnesota Chromatography Forum,6th Annual Fargo Mini-Symposium, Fargo, ND.
  • Karkhoff, R. and Knull, H.R. 1985. Glycolytic Enzyme Interaction with Bovine Brain Vesicles. West Central States Biochemistry Conference, Univ. of South Dakota, Vermillion, SD.
  • Laursen, Susan and Knull, H.R. 1985. Inositol Extraction, Measurement, and Use as a Marker for Membrane Porosity. West Central States Biochemistry Conference, University of South Dakota, Vermillion, SD.
  • Knull, H.R. 1985. Variable Extraction of Glycolytic Enzymes Mediated by Detergents. Amer. Soc. Neurochemistry, Baltimore, Maryland.
  • Knull, H.R. 1983. Glycolytic Enzyme Compartments in the Brain. The Cytoplasmic Matrix and Integration of Cellular Function Conference, Bethesda, Maryland.
  • Knull, H.R. and Fillmore, S.J. 1983. Glycolytic and Glycogen Metabolizing Enzymes in Synaptosomes, Amer. Soc. Neurochemistry, Honolulu, Hawaii.
  • Knull, H.R. 1983. Muscle Energy Metabolism: Effects of Exercise. North Dakota Academy of Science, Grand Forks, North Dakota.
  • Knull, H.R. 1982. Actin, Clathrin and Glycolytic Enzyme Interactions. Am. Soc. Neurochemistry, Grossinger, N.Y.
  • Cottick, A.A. and Knull, H.R. 1981. Proposed Ultrastructure at the Synaptosomal Membrane Involving Glycolytic Enzymes. Anatomical Record 149, 145. Amer. Assoc. Anatomists, Winnipeg, Canada.
  • Knull, H.R. 1980. Compartmentation of Glycolytic Enzymes in Nerve Endings. Amer. Soc. Neurochem. Houston, Texas. 
  • Knull, H.R. and Bronstein, W.W. 1979. Interaction of Glycolytic Enzymes with Thin Filament Proteins. International Congress of Biochemistry, Toronto, Ontario.
  • Bronstein, W.W. and Knull, H.R. 1978. Interaction of Glycolytic Enzymes with Actin. Can. Fed. Biol. Sci., London, Ontario.
  • Dawes, C. and Knull, H.R. 1978. The Effect of Stop Flow on the Composition of Human Parotid and Submandibular Saliva. I.A.D.R. April, Washington,D.C.
  • Dawes, C., Dowse, C.M. and Knull, H.R. 1978. The Effect of Stop-Flow on the Composition and Hydrostatic Pressures Developed in Human Parotid Saliva. European Organization for Caries Research. Turku, Finland.
  • Knull, H.R. and Suga, D. 1976. Particulate Nature of Several Glycolytic Enzymes in Brain. Can. Fed. Biol. Sci. Halifax, Nova Scotia.
  • Bose, D. and Knull, H.R. 1976. Mechanical and Biochemical Consequences of Anoxia and Substrate Deprivation in Smooth Muscle. Fed. Proc., Anaheim, CA.
  • Knull, H.R. and Suga, D. 1975. Some Properties of Bound Pyruvate Kinase in Rat Brain. Can. Fed. Biol. Sci. Abs. 649, Winnipeg, Manitoba.
  • Knull, H.R. and Taylor, W.F. 1973. Effect of Energy Metabolism on in vivo Distribution of Hexokinase in Brain. Fed. Proc., Atlantic City, New Jersey.
  • Wells, W.W. and Knull, H.R. 1973. Hexokinase Distribution: A Possible Index of Energy Status in Chick Brain. Int. Cong. Biochem., Stockholm, Sweden.
  • Knull, H.R. and Wells, W.W. 1972. Reversal of Galactose Neurotoxicity in Chicks by Glucose Injection. FASEB, Atlantic City, New Jersey.
  • Knull, H.R., Blosser, J.C. and Wells, W.W. 1971. Abnormal Glycoprotein Metabolism in Brains of Chicks Fed Toxic Levels of Galactose. FASEB, San Francisco, CA.
  • Knull, H.R., Cepure, A. and Pazur, J.H. 1970. A Suggestion on the Role of Carbohydrate Moieties in Glycoenzymes. Fed. Proc., Atlantic City, New Jersey.
  • Knull, H.R. and Pazur, J.H. 1970. Rapid Method for the Determination of Glucoamylases. Amer. Assoc. Cereal Chem. Mtg., October, Minneapolis, MN.
  • Pazur, J.H., Atienza, S.T. and Knull, H.R. 1970. Enzymic Procedures for the Determination of Structure of Carbohydrates. Amer.Chem.Soc. Toronto, Canada.
  • Knull, H.R., Simpson, D.L. and Pazur, J.H. 1969. Biosynthesis of Glucohydrolase, A glycoenzyme from Aspergillus niger. Amer.Chem.Soc.Mtg., Toronto, Canada.
  • Simpson, D.L., Knull, H.R. and Pazur, J.H. 1968. Biosynthetic Pathways for L-rhamnose in Plants. Amer. Chem. Soc. Mtg. Biol. #34, Atlantic City, NJ.
 
RESEARCH SEMINARS
  • Univ of Minnesota-Duluth, Dept. of Chemistry. "Particulate Nature of Glycolytic Enzymes in Brain". Dec. 1975
  • Univ of Manitoba, Department of Biochemistry. "Subcellular Compartmentation of Glycolytic Enzymes in Brain". Oct. 1976
  • North Dakota State Univ, Department of Biochemistry. "Compartmentation of Glycolytic Enzymes in Brain". Dec. 1977
  • Univ of Manitoba, Department of Chemistry. "Subcellular Compartmentation of Carbohydrate Metabolism". Jan. 1979
  • Univ of North Dakota, Department of Biochemistry. "Glycolytic Enzyme Localization in Brain". Feb. 1980
  • Pennsylvania State Univ, Department of Biochemistry. "Compartmentation of Glycolytic Enzymes in Brain: Role of the Cytoskeleton". Mar. 1982
  • Univ of South Dakota, Department of Biochemistry. "Glycolytic Enzyme Compartments in Brain: Relationship with the Slow Phases of Axonal Transport". May 1982
  • Univ of North Dakota, Sigma Xi Annual Banquet Speaker. "Cytoplasm: The Inside Story". April 1986
  • Michigan State Univ, Department of Biochemistry. "Compartmentation of Glycolytic Enzymes in the Brain". October 1986
  • University of Manitoba, Sigma Xi Exchange. "Cytoplasm: The Inside Story". Nov. 1986
  • Univ of Manitoba, Department of Oral Biology. "Interactions of Glycolytic Enzymes With the Cytoskeleton: Relationship to the Microtrabecular System". Nov. 1986
  • North Dakota State Univ, Sigma Xi Exchange Lecture. "Models of Cytoplasmic Organization". Nov 1987
  • Univ of North Dakota, Beaker Speaker-UND Chem Club. "A Peek Inside Cells, The Structure of Cytoplasm". Nov 1987
  • Univ of Minnesota-Duluth, Dept. of Chemistry. "Protein Interactions within the Cytoplasm". Feb. 1989
  • Univ of North Dakota, Dept of Anatomy and Cell Biology. "Axonal Transport and Interactions among Axoplasmic proteins". Mar. 1989
  • Univ of North Dakota, Dept of Biology. "Interactions of glycolytic enzymes with the cytoskeleton: Origins of cytoplasmic structure". Feb. 1, 1990
  • Lions International,District 5 Convention. "Diabetes and Blindness". June, 1989
  • Greater Grand Forks Dietetics Association. "Role of Non-enzymatic Reactions of glucose in Diabetes". May, 1990
  • Wright State University. "Role of the cytoskeleton in compartmentation of glycolytic enzymes" Mar. 1991
  • North Dakota State Univ. "Interactions among glycolytic enzymes and the cytoskeleton". Dec. 1991
  • Univ of North Dakota, Dept of Chemical Engineering. "Organization within the cytoplasm" Nov. 1992
  • Univ of North Dakota, Dept of Anatomy and Cell Biology. Association of soluble proteins with the cytoskeleton. Oct. 1993
  • Michigan State University. Role of the cytoskeleton in compartmentation of glycolytic enzymes. May 1997.
  • Oklahoma State Univ. ?Role of the Cytoskeleton in Compartmentation of glycolytic enzymes. Feb. 1998
 
SUPERVISORY ACTIVITIES: GRADUATE STUDENTS: Graduate Students I have mentored (Current employment in parentheses):
  1. Wayne Bronstein, 1977-1979 - M.S., University of Manitoba, "Association of Glycolytic Enzymes with Structural Proteins". (Boehringer-Engleheim Pharmaceuticals, Vancouver)
  2. RoxAnn Karkhoff-Schweizer - 1981-1988. Ph.D., University of North Dakota, "Biochemical Characterization of the Association Between Glycolytic Enzymes and Clathrin Coated Vesicles Using Centrifugation, Electrophoretic, and Ligand Blotting Techniques". (Professor of Microbiology, Colorado State)
  3. Julie Walsh - 1984-1988. Ph.D., University of North Dakota. "Glycolytic Enzyme Associations with Cytoskeletal and Microtrabecular Components". (Optometrist - Wabasha MN - completed accelerated Optometry program for persons with Ph.D. degree)
  4. Donna Carr - 1987-1989. M.S., University of North Dakota, "Characterization of glycolytic enzyme interactions with microtubules and subtilisin treated microtubules". (Schering Plough - NJ)
  5. Mike Brown - 1986-1992. MD/PhD, University of North Dakota. "Non-Enzymatic Glycation of Cytoskeletal Proteins in Diabetes Mellitus" (Thoracic Surgeon, Bismarck, ND)
  6. Tim Keith M.S. Dec. 1989-1991 - University of North Dakota. "Effects of tubulin and microtubules on activity of several glycolytic enzymes: Kinetic evidence for interactions" Ph.D. 1996 Involvement of the amino terminal of actin in actin-aldolase interactions (Professor, Chadron State)
  7. Warren Volker M.S. Aug. 1991-1993 - University of North Dakota. "Characterization of glycolytic enzyme-tubulin interactions: Enzyme facilitated network formation and effect of modifying tubulin C-terminals on enzyme binding" MD/PhD 1997 “A novel regulatory mechanism of glycolysis via glycolytic enzyme-tubulin interactions: Modulation by protein tyrosine kinase phosphorylation of tubulin” (Obstetrics and Gynecology Physician and Director of Research-UNLV)
  8. Carol Gustafson - M.S. 1964-1996. “Glycolytic enzyme interactions with wild type and mutant Saccharomyces cerevisciae actin: Comparison with skeletal muscle” (Quantech Ltd., Minneapolis, MN)
  9. Tanya Cox 1996-1997. M.S. “Tubulin phosphorylation, protein tyrosine kinases and glycolytic enzyme activities in breast cancer” (Resident in Emergency Medicine, University of Minnesota)
 
UNDERGRADUATE STUDENT RESEARCH SUPERVISION (*Entered medical school-now MD’s, ^Entered Graduate School-now have MS or PhD, #Dental Students-now dentists
*Michael Kruger, 1997-99, *T.J. Matzke, 1996-97,  *Billie Grieve, 1995-96, *^Tanya Cox, 1994-96, ^Carol Gustafson, 1993-94, Laura Wilkens, 1989-91, *Pat Luger, 1990-92, *Lew Radonowich, 1989-90, *Karen Sevigny, 1988-90, *Cindi Leech, 1988-89, *Tony Haas, 1988, *Douglas Loveless, 1987, ^Donna Carr 1986, *^Michael Brown 1986, Tim Shea 1984-85, ^Susan Hodel 1984, *Mark Koponen 1982, *Tom Haukas 1981, Steve Knudson 1981, #Alex Cottick 1981-82, #Sandra Lamb 1979, #Ron Isfeld 1977, Bruce Clark 1976-77, #Randy Law 1975.
 
SUPERVISORY ACTIVITIES: Postdoctoral Fellows
  • Philippe Marmillot, 1993-95
  • Catherine Reinitz, 1992-93
 
GRADUATE STUDENT COMMITTEES
  1. Robert Kapitany, 1975, Ph.D., Oral Biology - Univ. of Manitoba -"Purification & Structure of the Major Secretory Submandibular Gland Glycoprotein".
  2. Bill Pohajdak, 1979, M.S., Microbiology - Univ. of Manitoba - "Keto Butyrate Dehydrogenase from Pseudomonas".
  3. Terry Spearman, 1979, Ph.D., Oral Biology - Univ. of Manitoba - "Role of calcium and Cyclic GMP in Salivary Gland Secretion".
  4. Lois Schwarz, 1980, M.S., Biochemistry - Univ. of Manitoba - "Calmodulin Effects on Actin Polymerization".
  5. LaVaun McCann, 1983, M.S., Anatomy - UND - "A Quantitative Analysis of the Synaptic Arrangements in the Adult Cat Cuneate Nucleus".
  6. Dan Dalan, 1983, M.S., Microbiology - UND - "An Evaluation of Bacterial Flagella Staining Procedures.
  7. Susan Hodel, 1983, M.S., Microbiology - UND - "An Evaluation of the Bacterial Flora of the Inner Nasal Cavity (Inferior Nasal Meatus).
  8. Louise Henrikson, 1984, M.S., Health and Physical Education - UND "A Comparison of Methods to Measure Caloric Expenditure During Exercise".
  9. Chris Whelan, 1985, Ph.D., Microbiology - UND - "Characterization of Humoral Responsiveness of Cattle and Guinea Pigs to Infestations with Ixodid Ticks".
  10. Jon Jackson, 1986, M.S., Anatomy - UND - "The Effects of 6 Diazo 5 oxo L-norleucine on the Development of the Otic Vesicle in the Chick Embryo: An in vitro Study.
  11. Lowell Nelson, 1986, Ph.D., Biochemistry and Molecular Biology - UND - "Regulation of the Solubility of Zinc in Milk".
  12. Wolfgang Gallwitz, 1986, Ph.D., Biochemistry and Molecular Biology - UND -"Characterization of Certain Physical Properties of the Cytoplasmic and Mitochondrial Forms of PEPCK in Rabbit Liver".
  13. Lisa Tuel, 1986, M.S., Biochemistry and Molecular Biology - UND - "Distribution and Properties of Phosphoenolpyruvate Carboxykinase Isoenzymes".
  14. Dale A. Schuschke, 1987. Ph.D., Physiology - UND - "Histamine Receptors and Cyclic AMP Levels in Rabbit Coronary Arteries".
  15. Roger Traxinger, 1987. Ph.D., Biochemistry and Molecular Biology - UND -"Studies on the Enzymes Involved in Futile Cycling Between Hepatic Glucose and Glucose-6-Phosphate".
  16. Jay Berger, 1987. Ph.D., Anatomy - UND - "Basement Membrane Heterogeneity: A High Resolution SEM Study of Renal Basement Membrane Ultrastructure Following Enzymic Micro-dissection.
  17. Valerie Howard, 1988. Ph.D., Microbiology - UND - "Identification and Characterization of Ixodid Tick Antigens Involved in Acquired Host Resistance to Infestation".
  18. Eric Linnell, 1988. Ph.D., Chemistry - "Synthesis of Modified Nucleosides and Nucleotides".
  19. Wai-Kwok Patrick Shum, 1988. Ph.D., Chemistry - "Synthesis and Characterization of a New Fluorine Substituted Nonionic Dinucleoside Phosphonate Analog,3',5'-Bis (deoxythymidine)Difluoromethylphosphonate".
  20. Brian Robbins, 1988. Ph.D., Biochemistry & Molecular Biology, "The Interaction of Multi-functional Glucose-6-Phosphatase with Select Metabolites".
  21. Monte Leidenix, 1988. M.S., Microbiology and Immunology, "Nonrandom Distribution of Penicillin Binding Proteins in Escherichia coli as Determined by Electrophoresis and Sephacryl S-1000 Chromatography".
  22. Kerry Nelson, 1988. M.S., Biochemistry & Molecular Biology, "Regulation of Glucose-6-Phosphate Hydrolysis in Fasted and Diabetic Rats and Tumor-Bearing Mice at Near-Physiological Substrate Concentrations".
  23. Eddie Kadrmas, 1989. MD/PhD, Biochemistry & Molecular Biology, "Guanine Nucleotide-Utilizing Enzymes in the Matrix of Mitochondria from Rabbit Heart and Liver:Nucleoside Diphosphate Kinase, Succinate Thiokinase, and Phosphoenolpyruvate Carboxykinase".
  24. Maria Statton, 1989. Ph.D. Anatomy and Cell Biology - UND - "A Morphological Study of Paracrine Interactions in the Anterior Pituitary of Lactating Rats using Immunogold Techniques".
  25. Rich Lucius, 1991. M.S. Biochemistry and Molecular Biology, "The in vivo effects of Ehrlich acites tumors on the hepatic glucose-6-phosphatase system".
  26. Thomas Wiese, 1990. Ph.D. Biochemistry and Molecular Biology, "Species and Tissue Specific Distribution of Mitochondrial and Cytoplasmic Isozymes of Phosphoenolpyruvate Carboxykinase".
  27. Debra Fry, 1991. M.S. Physiology, "Measurement of Ascorbic Acid and Dehydroascrobic Acid in Mammalian Tissue using HPLC with Electrochemical Detection".
  28. Diane Kube, 1991. Ph.D. Biochemistry and Molecular Biology, "Regulation of the Nucleosome-Free Promoter Region of Simian Virus 40".
  29. Allan Forsman, 1991. Ph.D. Department of Anatomy and Cell Biology, "The Blood-Oocyte Barrier: Morphological Evidence Implicating the Zona Pellucida".
  30. Sue Marion, Dec. 1992, Ph.D. Department of Anatomy and Cell Biology, "Localization and Quantitation of Maillard Reaction Products in Bovine Anterior Lens Capsules and Descemet's Membranes by Immunoelectron Microscopy".
  31. Joe Provost, 1994, Ph.D. Biochemistry and Molecular Biology, "Interactions Between Enzymes Metabolizing Oxaloacetate and Phosphoenolpyruvate in Rabbit Liver Cytosol"
  32. Maureen Robinson, 1994, M.S. Biochemistry and Molecular Biology, "Type 1 cAMP-Dependent Protein Kinase is Associated with Cardiac Myocyte Sarcolemma"
  33. Jamie Foster, 1994, Ph.D. Biochemistry and Molecular Biology "Selective Labeling and Characterization of Glucose-6-Phosphatase Specific Translocase T1 of the Glucose-6-Phosphatase System".
  34. Robin Arneson 1997 M.S. ?The effect of oxidative modification of glyceraldehyde-3-phosphate dehydrogenase and aldolase on their interaction with microtubules?
  35. Michelle Lemon 1997 M.S. ?The effect of oxidative modification on the association of glyceraldehyde-3-phosphate dehydrogenase and aldolase with F-actin?
  36. Bill Morgan 1996-8, Thesis Committee, (did not complete - went to Medical School) Microbiology and Immunology, Advisor-Ann Flower
  37. Laura Streng 1998. Thesis Committee, Anatomy and Cell Biology, Advisor-Ed Carlson. A Biochemical Analysis of Proteoglycans Synthesized by Bovine Retinal Pericytes in Culture
  38. Carl Wald 2002. Ph.D. Biochemistry and Molecular Biology,
 
COMMITTEES AT UND:
Medical School
Medical School Animal Care Committee. 1980-81
Medical School Library Committee. 1981-84
Chair 1983-84
Medical School Focal Problems Committee. 1981-87
Medical School Student Performance and Recognition. 1983-86
Medical School Research Committee. 1983-89
Chair 1987-89
Medical School MANDAK Committee. 1984-86
Education Policy & Curriculum Committee 1984-86
Education Policy & Curriculum Committee 1987-90
Chair, Search Committee for Physiology Chairperson. 1988
Alcohol and Drug Abuse in the curriculum 1988-91
Campus:
Faculty Senate. 1985-86, 1990-present
Graduate Committee 1987-90
Chair 1989-90
Sigma Xi Awards Committee. 1987-1991
Sigma Xi Nominations Committee. 1987-1990
Diversity Committee 1992-1995
Chair of the Search Committee for the Director of UND’s Research Office 1996
Chair of the Search Committee for the President of UND 1998-99
Several others, (e.g., Chester Fritz Distinguished Professor selection Committee, Honorary Degrees Committee, Provost/VPAA search Committee) 1990-
Served on several committees at the University of Manitoba including the Dental School Representative to the U of M Faculty Association and Dental School Admissions Committee.
 
PROFESSIONAL ORGANIZATIONS
  • American Society for Biological Chemists
  • Sigma Xi
  • Phi Lambda Upsilon - Honorary Chemistry Fraternity.
 
OTHER ORGANIZATIONS
  • Grand Forks Economic Development Corporation (2000-2003)
  • Member of Grand Forks County Extension Advisory Board (1985-1991)
  • Grand Forks Master Gardener
 
Seminar/Lecture/Roundtable
  • Ed Leadership classes - Topics, The Graduate School, Selecting a President, Mentoring.
  • Alice Clark Mentorship Program

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